Region: West | East | South | Midwest | Final 4 |
| 2022 NCAA Men's Basketball Tournament Bracket - South Region | ||||
| Final 4 | Elite 8 | Sweet 16 | 2nd Round | 1st Round |
| 1.) Arizona | ||||
| 87-70 (F)
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| South Region | 1.) Arizona | |||
| 85-80 (F-OT)
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| 16.) Wright State | ||||
| 1.) Arizona | ||||
| 60-72 (F)
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8.) Seton Hall | |||
| 42-69 (F)
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| 9.) TCU | ||||
| 9.) TCU | ||||
| 5.) Houston | ||||
| 50-44 (F)
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5.) Houston | |||
| 82-68 (F)
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| 5.) Houston | ||||
| 53-68 (F)
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| 12.) UAB | ||||
| 5.) Houston | ||||
| 4.) Illinois | ||||
| 54-53 (F)
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| 4.) Illinois | ||||
| 13.) Chattanooga | ||||
| 2.) Villanova | ||||
| Champion (South Region) |
6.) Colorado State | |||
| 63-75 (F)
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| 11.) Michigan | ||||
| 68-76 (F)
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| 11.) Michigan | ||||
| 11.) Michigan | ||||
| 63-55 (F)
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3.) Tennessee | |||
| 88-56 (F)
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| 3.) Tennessee | ||||
| 14.) Longwood | ||||
| 2.) Villanova | ||||
| 7.) Ohio State | ||||
| 54-41 (F)
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| 7.) Ohio State | ||||
| 71-61 (F)
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| 10.) Loyola Chicago | ||||
| 2.) Villanova | ||||
| 2.) Villanova | ||||
| 80-60 (F)
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| South Region | 2.) Villanova | |||
| 15.) Delaware | ||||
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