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| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 22 - Apr. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Leonardo Mayer |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 14 - Apr. 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roberto Bautista Agut | Win | 6-1, 6-1 |
| Third Round | Grigor Dimitrov | Win | 6-4, 6-1 |
| Quarterfinals | Guido Pella | Win | 7-6 (7-1), 6-3 |
| Semifinals | Fabio Fognini | Loss | 4-6, 2-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 6 - Mar. 17 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jared Donaldson | Win | 6-1, 6-1 |
| Third Round | Diego Schwartzman | Win | 6-3, 6-1 |
| Fourth Round | Filip Krajinovic | Win | 6-3, 6-4 |
| Quarterfinals | Karen Khachanov | Win | 7-6 (7-2), 7-6 (7-2) |
| Semifinals | Roger Federer | Loss | Retired |
| Abierto Mexicano TELCEL presentado por HSBC | ||
| Surface: Hard | Date: Feb. 25 - Mar. 3 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Mischa Zverev | Win | 6-3, 6-3 |
| Second Round | Nick Kyrgios | Loss | 6-3, 6-7 (2-7), 6-7 (6-8) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 14 - Jan. 27 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | James Duckworth | Win | 6-4, 6-3, 7-5 |
| Second Round | Matthew Ebden | Win | 6-3, 6-2, 6-2 |
| Third Round | Alex De Minaur | Win | 6-1, 6-2, 6-4 |
| Fourth Round | Tomas Berdych | Win | 6-0, 6-1, 7-6 (7-4) |
| Quarterfinals | Frances Tiafoe | Win | 6-3, 6-4, 6-2 |
| Semifinals | Stefanos Tsitsipas | Win | 6-2, 6-4, 6-0 |
| Final | Novak Djokovic | Loss | 3-6, 2-6, 3-6 |
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