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| Nitto ATP Finals | ||
| Surface: Hard | Date: Nov. 13 - Nov. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| Round Robin | Taylor Fritz | Loss | 6-7 (3-7), 1-6 3-6, 4-6 7-5, 7-5 |
| Round Robin | Felix Auger-Aliassime | Loss | 6-7 (3-7), 1-6 3-6, 4-6 7-5, 7-5 |
| Round Robin | Casper Ruud | Win | 6-7 (3-7), 1-6 3-6, 4-6 7-5, 7-5 |
| Rolex Paris Masters | ||
| Surface: Hard | Date: Oct. 31 - Nov. 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tommy Paul | Loss | 6-3, 6-7 (4-7), 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Rinky Hijikata | Win | 4-6, 6-2, 6-3, 6-3 |
| Second Round | Fabio Fognini | Win | 2-6, 6-4, 6-2, 6-1 |
| Third Round | Richard Gasquet | Win | 6-0, 6-1, 7-5 |
| Fourth Round | Frances Tiafoe | Loss | 4-6, 6-4, 4-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Borna Coric | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Francisco Cerundolo | Win | |
| Second Round | Ricardas Berankis | Win | |
| Third Round | Lorenzo Sonego | Win | |
| Fourth Round | Botic van de Zandschulp | Win | |
| Quarterfinals | Taylor Fritz | Win | |
| Semifinals | Nick Kyrgios | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jordan Thompson | Win | |
| Second Round | Corentin Moutet | Win | |
| Third Round | Botic van de Zandschulp | Win | |
| Fourth Round | Felix Auger-Aliassime | Win | |
| Quarterfinals | Novak Djokovic | Win | |
| Semifinals | Alexander Zverev | Win | |
| Final | Casper Ruud | Win |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | John Isner | Win | |
| Third Round | Denis Shapovalov | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Miomir Kecmanovic | Win | |
| Third Round | David Goffin | Win | |
| Quarterfinals | Carlos Alcaraz | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sebastian Korda | Win | |
| Third Round | Daniel Evans | Win | |
| Fourth Round | Reilly Opelka | Win | |
| Quarterfinals | Nick Kyrgios | Win | |
| Semifinals | Carlos Alcaraz | Win | |
| Final | Taylor Fritz | Loss |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 21 - Feb. 26 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Denis Kudla | Win | |
| Second Round | Stefan Kozlov | Win | |
| Quarterfinals | Tommy Paul | Win | |
| Semifinals | Daniil Medvedev | Win | |
| Final | Cameron Norrie | Win |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Marcos Giron | Win | |
| Second Round | Yannick Hanfmann | Win | |
| Third Round | Karen Khachanov | Win | |
| Fourth Round | Adrian Mannarino | Win | |
| Quarterfinals | Denis Shapovalov | Win | |
| Semifinals | Matteo Berrettini | Win | |
| Final | Daniil Medvedev | Win |
| Melbourne Summer Set 1 | ||
| Surface: Hard | Date: Jan. 4 - Jan. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ricardas Berankis | Win | |
| Quarterfinals | Tallon Griekspoor | Win | |
| Semifinals | Emil Ruusuvuori | Win | |
| Final | Maxime Cressy | Win |
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