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| Rolex Shanghai Masters | ||
| Surface: Hard | Date: Oct. 7 - Oct. 14 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Andrey Rublev | Win | 6-3, 6-4 |
| Second Round | Mackenzie McDonald | Win | 3-6, 6-4, 6-1 |
| Third Round | Roger Federer | Loss | 3-6, 6-2, 4-6 |
| China Open | ||
| Surface: Hard | Date: Sep. 29 - Oct. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alexander Zverev | Loss | 4-6, 4-6 |
| St. Petersburg Open | ||
| Surface: Hard | Date: Sep. 17 - Sep. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Luca Vanni | Win | 7-5, 6-2 |
| Second Round | Mikhail Youzhny | Win | 7-6 (8-6), 3-6, 6-3 |
| Quarterfinals | Marco Cecchinato | Win | 7-6 (7-0), 6-3 |
| Semifinals | Dominic Thiem | Loss | 4-6, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 19 |
| Round | Opponent | W / L | Result |
| First Round | Jason Kubler | Loss | 3-6, 3-6, 4-6 |
| J. Safra Sarasin Suisse Open Gstaad | ||
| Surface: Clay | Date: Jul. 23 - Jul. 29 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jaume Munar | Win | 2-6, 6-3, 6-2 |
| Quarterfinals | Taro Daniel | Win | 7-5, 6-1 |
| Semifinals | Laslo Djere | Win | 6-7 (5-7), 6-4, 6-4 |
| Final | Matteo Berrettini | Loss | 6-7 (9-11), 4-6 |
| Gerry Weber Open | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Jan-Lennard Struff | Win | 6-4, 6-1 |
| Second Round | Robin Haase | Win | 6-4, 7-5 |
| Quarterfinals | Karen Khachanov | Win | 6-3, 6-7 (3-7), 6-3 |
| Semifinals | Borna Coric | Loss | 3-2 Retired |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Denis Istomin | Win | 6-2, 6-7 (3-7), 1-6, 6-4, 6-4 |
| Second Round | Santiago Giraldo | Win | 6-4, 7-5, 6-3 |
| Third Round | Novak Djokovic | Loss | 4-6, 7-6 (8-6), 6-7 (4-7), 2-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Jared Donaldson | Win | 6-7 (3-7), 6-4, 6-4 |
| Second Round | Philipp Kohlschreiber | Loss | 3-6, 6-4, 5-7 |
| BMW Open by FWU | ||
| Surface: Red Clay | Date: Apr. 30 - May 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Casper Ruud | Win | 6-4, 6-3 |
| Quarterfinals | Philipp Kohlschreiber | Loss | 4-6, 4-6 |
| Barcelona Open Banco Sabadell | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ivo Karlovic | Win | 6-7 (4-7), 6-2, 6-4 |
| Third Round | Pablo Andujar | Win | 6-4, 6-1 |
| Quarterfinals | David Goffin | Loss | 7-6 (7-3), 2-6, 2-6 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 15 - Apr. 22 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Peter Gojowczyk | Win | 6-4, 6-3 |
| Second Round | Feliciano Lopez | Win | 6-3, 7-6 (7-5) |
| Third Round | David Goffin | Loss | 4-6, 5-7 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Michael Mmoh | Loss | 6-7 (4-7), 6-2, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jared Donaldson | Win | 6-4, 6-2 |
| Third Round | Borna Coric | Loss | 1-6, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 26 - Mar. 3 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Florian Mayer | Win | 6-3, 6-4 |
| Second Round | Pierre-Hugues Herbert | Win | 6-4, 6-7 (2-7), 6-1 |
| Quarterfinals | Borna Coric | Win | 7-6 (7-4), 6-4 |
| Semifinals | Malek Jaziri | Win | 6-3, 6-4 |
| Final | Lucas Pouille | Win | 6-3, 6-4 |
| Open 13 Marseille | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Julien Benneteau | Loss | 6-7 (2-7), 6-7 (5-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Fernando Verdasco | Loss | 1-6, 5-7, 5-7 |
| Tata Open Maharashtra | ||
| Surface: Hard | Date: Jan. 1 - Jan. 6 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gilles Simon | Loss | 3-6, 6-7 (5-7) |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 1 - Jan. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Michael Venus | Win | 6-2, 6-1 |
| Second Round | Steve Johnson | Win | 2-6, 6-2, 6-1 |
| Quarterfinals | Jiri Vesely | Win | 7-6 (7-1), 6-2 |
| Semifinals | Robin Haase | Win | 6-7 (7-9), 7-6 (7-3), 7-6 (7-5) |
| Final | Juan Martin Del Potro | Win | 6-1, 4-6, 7-5 |
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