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| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 11 - Apr. 18 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Taylor Fritz | Win | 6-2, 7-5 |
| Second Round | Tommy Paul | Win | 6-3, 6-4 |
| Third Round | Andrey Rublev | Loss | 6-7 (2-7), 7-5, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lloyd Harris | Win | Retired |
| Third Round | Jan-Lennard Struff | Win | 4-6, 6-3, 6-2 |
| Fourth Round | John Isner | Win | 6-3, 4-6, 7-6 (9-7) |
| Quarterfinals | Daniil Medvedev | Win | 6-4, 6-2 |
| Semifinals | Jannik Sinner | Loss | 7-5, 4-6, 4-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 14 - Mar. 20 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matthew Ebden | Win | 4-1 Retired |
| Third Round | Jannik Sinner | Loss | 4-6, 6-3, 5-7 |
| Qatar ExxonMobil Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Reilly Opelka | Win | 4-6, 6-3, 6-4 |
| Second Round | Alexander Bublik | Win | 6-4, 6-3 |
| Quarterfinals | Dominic Thiem | Win | 7-6 (7-3), 2-6, 6-4 |
| Semifinals | Andrey Rublev | Win | 6-3, 6-3 |
| Final | Nikoloz Basilashvili | Loss | 6-7 (5-7), 2-6 |
| ABN AMRO World Tennis Tournament | ||
| Surface: Hard | Date: Mar. 1 - Mar. 7 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Alejandro Davidovich Fokina | Loss | 2-6, 6-7 (3-7) |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 22 - Feb. 28 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gregoire Barrere | Win | 6-0, 6-3 |
| Quarterfinals | Ugo Humbert | Win | 6-3, 6-3 |
| Semifinals | Peter Gojowczyk | Win | 7-5, 6-1 |
| Final | David Goffin | Loss | 7-5, 4-6, 2-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Radu Albot | Loss | 7-6 (7-1), 0-6, 4-6, 6-7 (5-7) |
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