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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Laura Siegemund | Win | 3-6, 6-2, 6-4 |
| Second Round | Mirra Andreeva | Win | 6-3, 6-2 |
| Third Round | Elise Mertens | Win | 3-6, 6-3, 6-0 |
| Fourth Round | Caroline Wozniacki | Win | 6-3, 3-6, 6-1 |
| Quarterfinals | Jelena Ostapenko | Win | 6-0, 6-2 |
| Semifinals | Karolina Muchova | Win | 6-4, 7-5 |
| Final | Aryna Sabalenka | Win | 2-6, 6-3, 6-2 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mayar Sherif | Win | 6-2, 6-2 |
| Third Round | Linda Noskova | Win | 6-4, 6-0 |
| Quarterfinals | Jasmine Paolini | Win | 6-3, 6-2 |
| Semifinals | Iga Swiatek | Win | 7-6 (7-2), 3-6, 6-4 |
| Final | Karolina Muchova | Win | 6-3, 6-4 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Katie Boulter | Win | 6-2, 6-2 |
| Third Round | Marketa Vondrousova | Win | 6-3, 6-0 |
| Quarterfinals | Jessica Pegula | Loss | 2-6, 7-5, 5-7 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Sofia Kenin | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | |
| Second Round | Jodie Burrage | Win | |
| Quarterfinals | Jessica Pegula | Win | |
| Semifinals | Madison Keys | Loss |
| Bett1 Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | |
| Second Round | Ekaterina Alexandrova | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Rebeka Masarova | Win | |
| Second Round | Julia Grabher | Win | |
| Third Round | Mirra Andreeva | Win | |
| Fourth Round | Anna Karolina Schmiedlova | Win | |
| Quarterfinals | Iga Swiatek | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | |
| Third Round | Marie Bouzkova | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 25 - May 6 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Irene Burillo Escorihuela | Win | |
| Third Round | Paula Badosa | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Veronika Kudermetova | Win | |
| Second Round | Anastasia Potapova | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Rebecca Marino | Win | |
| Third Round | Anastasia Potapova | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Cristina Bucsa | Win | |
| Third Round | Linda Noskova | Win | |
| Fourth Round | Rebecca Peterson | Win | |
| Quarterfinals | Aryna Sabalenka | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aliaksandra Sasnovich | Win | |
| Third Round | Elena Rybakina | Win | |
| Quarterfinals | Madison Keys | Win | |
| Semifinals | Iga Swiatek | Loss |
| Qatar Total Energies Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Petra Kvitova | Win | |
| Quarterfinals | Veronika Kudermetova | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Katerina Siniakova | Win | |
| Second Round | Emma Raducanu | Win | |
| Third Round | Bernarda Pera | Win | |
| Fourth Round | Jelena Ostapenko | Loss |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Tatjana Maria | Win | |
| Second Round | Sofia Kenin | Win | |
| Quarterfinals | Lin Zhu | Win | |
| Semifinals | Danka Kovinic | Win | |
| Final | Rebeka Masarova | Win |
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