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| Connecticut Open presented by United Technologies | ||
| Surface: Hard | Date: Aug. 19 - Aug. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Victoria Azarenka | Win | 6-4, 7-5 |
| Third Round | Aryna Sabalenka | Loss | 4-6, 6-3, 5-7 |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magdalena Rybarikova | Win | 4-6, 6-1, 6-3 |
| Third Round | Maria Sharapova | Win | 6-3, 6-2 |
| Quarterfinals | Simona Halep | Loss | 5-7, 1-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Belinda Bencic | Loss | 6-7 (2-7), 3-6 |
| Mallorca Open | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Su-Wei Hsieh | Win | 7-6 (7-4), 1-6, 6-4 |
| Second Round | Johanna Larsson | Win | 6-4, 6-3 |
| Quarterfinals | Sofia Kenin | Loss | 3-6, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Ying-Ying Duan | Win | 6-1, 6-0 |
| Second Round | Shuai Peng | Win | 6-4, 3-6, 6-3 |
| Third Round | Irina-Camelia Begu | Win | 6-1, 6-3 |
| Fourth Round | Angelique Kerber | Loss | 2-6, 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Timea Babos | Win | 6-3, 6-4 |
| Third Round | Sloane Stephens | Win | 6-1, 7-6 (9-7) |
| Quarterfinals | Simona Halep | Loss | 2-6, 3-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Dominika Cibulkova | Win | 6-1, 7-5 |
| Second Round | Petra Martic | Win | 6-3, 7-5 |
| Third Round | Julia Goerges | Win | 6-2, 6-4 |
| Quarterfinals | Carla Suarez Navarro | Win | 6-2, 6-3 |
| Semifinals | Kiki Bertens | Loss | 2-6, 2-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Maria Sharapova | Win | 3-6, 7-6 (8-6), 6-4 |
| Second Round | Marta Kostyuk | Win | 6-1, 3-6, 7-5 |
| Quarterfinals | Elina Svitolina | Win | 6-7 (4-7), 6-4, 6-2 |
| Semifinals | Coco Vandeweghe | Loss | 4-6, 2-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 2 - Apr. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Varvara Lepchenko | Win | 6-2, 6-3 |
| Third Round | Alize Cornet | Loss | 7-5, 1-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Riske | Loss | 3-6, 1-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jennifer Brady | Win | 6-4, 6-4 |
| Third Round | Daria Gavrilova | Win | 7-5, 6-4 |
| Fourth Round | Angelique Kerber | Loss | 1-6, 1-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 24 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Lucie Safarova | Win | 6-3, 7-5 |
| Second Round | Ekaterina Makarova | Win | 6-4, 6-2 |
| Quarterfinals | Garbine Muguruza | Loss | 5-7, 2-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominika Cibulkova | Win | 6-3, 6-7 (3-7), 6-0 |
| Third Round | Anna Blinkova | Win | 7-6 (7-3), 7-5 |
| Quarterfinals | Garbine Muguruza | Loss | 6-3, 1-6, 4-6 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Jan. 29 - Feb. 4 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elena Rybakina | Loss | 6-4, 6-7 (6-8), 6-7 (5-7) |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Carina Witthoeft | Win | 7-5, 6-3 |
| Second Round | Marketa Vondrousova | Win | 6-7 (3-7), 6-2, 8-6 |
| Third Round | Aliaksandra Sasnovich | Win | 6-3, 5-7, 6-2 |
| Fourth Round | Madison Keys | Loss | 3-6, 2-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 7 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Alize Cornet | Loss | 6-3, 3-6, 0-0 Retired |
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