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| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Nina Stojanovic | Win | 6-4, 6-7 (4-7), 6-0 |
| Second Round | Tamara Zidansek | Win | 6-3, 6-1 |
| Third Round | Danielle Collins | Win | 6-3, 6-3 |
| Fourth Round | Elise Mertens | Win | 6-4, 6-1 |
| Quarterfinals | Barbora Krejcikova | Win | 6-1, 6-4 |
| Semifinals | Leylah Fernandez | Loss | 6-7 (3-7), 6-4, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 15 - Aug. 22 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Paula Badosa | Loss | 7-5, 2-6, 6-7 (4-7) |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sloane Stephens | Win | 7-6 (7-4), 4-6, 6-4 |
| Third Round | Rebecca Marino | Win | 6-1, 6-3 |
| Quarterfinals | Victoria Azarenka | Win | 6-2, 6-4 |
| Semifinals | Karolina Pliskova | Loss | 3-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Monica Niculescu | Win | 6-1, 6-4 |
| Second Round | Katie Boulter | Win | 4-6, 6-3, 6-3 |
| Third Round | Maria Camila Osorio Serrano | Win | 6-0, 6-3 |
| Fourth Round | Elena Rybakina | Win | 6-3, 4-6, 6-3 |
| Quarterfinals | Ons Jabeur | Win | 6-4, 6-3 |
| Semifinals | Karolina Pliskova | Loss | 7-5, 4-6, 4-6 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 21 - Jun. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | 6-3, 6-4 |
| Second Round | Alison Riske | Win | 6-1, 6-4 |
| Quarterfinals | Camila Giorgi | Loss | 6-7 (5-7), 6-0, 4-6 |
| bett1open | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Madison Keys | Loss | 4-6, 6-1, 5-7 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Ana Konjuh | Win | 6-4, 6-3 |
| Second Round | Aliaksandra Sasnovich | Win | 7-5, 6-3 |
| Third Round | Anastasia Pavlyuchenkova | Loss | 4-6, 6-2, 0-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sara Sorribes Tormo | Win | 7-5, 6-1 |
| Third Round | Cori Gauff | Loss | 5-7, 3-6 |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Vera Zvonareva | Win | 6-1, 6-2 |
| Second Round | Daria Kasatkina | Win | 6-3, 6-3 |
| Third Round | Jessica Pegula | Win | 6-1, 6-2 |
| Quarterfinals | Elise Mertens | Win | 6-1, 4-0 Retired |
| Semifinals | Anastasia Pavlyuchenkova | Win | 6-2, 6-3 |
| Final | Ashleigh Barty | Win | 6-0, 3-6, 6-4 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 19 - Apr. 25 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Shuai Zhang | Win | 6-2, 6-2 |
| Second Round | Anna-Lena Friedsam | Win | 6-4, 6-2 |
| Quarterfinals | Anett Kontaveit | Win | 7-5, 4-6, 6-1 |
| Semifinals | Simona Halep | Win | 6-3, 6-2 |
| Final | Ashleigh Barty | Loss | 6-3, 0-6, 3-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tsvetana Pironkova | Win | 0-6, 6-3, 7-6 (11-9) |
| Third Round | Veronika Kudermetova | Win | 7-6 (7-4), 6-4 |
| Fourth Round | Marketa Vondrousova | Win | 6-1, 6-2 |
| Quarterfinals | Ashleigh Barty | Loss | 4-6, 7-6 (7-5), 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Win | 6-2, 6-4 |
| Third Round | Anett Kontaveit | Win | 6-3, 6-2 |
| Quarterfinals | Garbine Muguruza | Loss | 6-3, 3-6, 2-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Garbine Muguruza | Loss | 2-6, 7-6 (7-5), 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Viktoria Kuzmova | Win | 6-0, 6-4 |
| Second Round | Daria Kasatkina | Win | 7-6 (7-5), 6-3 |
| Third Round | Ann Li | Win | 6-3, 6-1 |
| Fourth Round | Serena Williams | Loss | 4-6, 6-2, 4-6 |
| Gippsland Trophy | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kaia Kanepi | Loss | 1-6, 6-2, 1-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 7-6 (7-5), 6-2 |
| Second Round | Ajla Tomljanovic | Win | 7-5, 6-4 |
| Third Round | Ons Jabeur | Win | 6-2, 6-4 |
| Quarterfinals | Elena Rybakina | Win | 6-4, 4-6, 6-3 |
| Semifinals | Maria Sakkari | Win | 6-3, 6-2 |
| Final | Veronika Kudermetova | Win | 6-2, 6-2 |
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