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| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tsvetana Pironkova | Win | 0-6, 6-3, 7-6 (11-9) |
| Third Round | Veronika Kudermetova | Win | 7-6 (7-4), 6-4 |
| Fourth Round | Marketa Vondrousova | Win | 6-1, 6-2 |
| Quarterfinals | Ashleigh Barty | Loss | 4-6, 7-6 (7-5), 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Win | 6-2, 6-4 |
| Third Round | Anett Kontaveit | Win | 6-3, 6-2 |
| Quarterfinals | Garbine Muguruza | Loss | 6-3, 3-6, 2-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Garbine Muguruza | Loss | 2-6, 7-6 (7-5), 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Viktoria Kuzmova | Win | 6-0, 6-4 |
| Second Round | Daria Kasatkina | Win | 7-6 (7-5), 6-3 |
| Third Round | Ann Li | Win | 6-3, 6-1 |
| Fourth Round | Serena Williams | Loss | 4-6, 6-2, 4-6 |
| Gippsland Trophy | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kaia Kanepi | Loss | 1-6, 6-2, 1-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Polona Hercog | Win | 7-6 (7-5), 6-2 |
| Second Round | Ajla Tomljanovic | Win | 7-5, 6-4 |
| Third Round | Ons Jabeur | Win | 6-2, 6-4 |
| Quarterfinals | Elena Rybakina | Win | 6-4, 4-6, 6-3 |
| Semifinals | Maria Sakkari | Win | 6-3, 6-2 |
| Final | Veronika Kudermetova | Win | 6-2, 6-2 |
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