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| WTA Finals Fort Worth | ||
| Surface: Hard | Date: Oct. 31 - Nov. 7 | Seed: 7 |
| Round | Opponent | W / L | Result |
| Round Robin | Ons Jabeur | Win | 3-6, 7-6 (7-5), 7-5 2-6, 4-6 6-3, 7-5 |
| Round Robin | Maria Sakkari | Loss | 3-6, 7-6 (7-5), 7-5 2-6, 4-6 6-3, 7-5 |
| Round Robin | Jessica Pegula | Win | 3-6, 7-6 (7-5), 7-5 2-6, 4-6 6-3, 7-5 |
| Semifinals | Iga Swiatek | Win | 6-2, 2-6, 6-1 |
| Final | Caroline Garcia | Loss | 6-7 (4-7), 4-6 |
| Guadalajara Open Akron | ||
| Surface: Hard | Date: Oct. 17 - Oct. 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Liudmila Samsonova | Loss | 4-6, 6-2, 2-6 |
| San Diego Open | ||
| Surface: Hard | Date: Oct. 10 - Oct. 16 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sloane Stephens | Win | 1-6, 6-3, 6-2 |
| Quarterfinals | Donna Vekic | Loss | 4-6, 7-6 (7-5), 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Catherine Harrison | Win | 6-1, 6-3 |
| Second Round | Kaia Kanepi | Win | 2-6, 7-6 (10-8), 6-4 |
| Third Round | Clara Burel | Win | 6-0, 6-2 |
| Fourth Round | Danielle Collins | Win | 3-6, 6-3, 6-2 |
| Quarterfinals | Karolina Pliskova | Win | 6-1, 7-6 (7-4) |
| Semifinals | Iga Swiatek | Loss | 6-3, 1-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anna Kalinskaya | Win | |
| Third Round | Shelby Rogers | Win | |
| Quarterfinals | Shuai Zhang | Win | |
| Semifinals | Caroline Garcia | Loss |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sara Sorribes Tormo | Win | |
| Third Round | Coco Gauff | Loss |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 1 - Aug. 7 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Caroline Dolehide | Win | |
| Quarterfinals | Daria Kasatkina | Loss |
| bett1open | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Veronika Kudermetova | Loss |
| Libema Open | ||
| Surface: Grass | Date: Jun. 6 - Jun. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Kateryna Baindl | Win | |
| Second Round | Arianne Hartono | Win | |
| Quarterfinals | Alison Van Uytvanck | Win | |
| Semifinals | Shelby Rogers | Win | |
| Final | Ekaterina Alexandrova | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Chloe Paquet | Win | |
| Second Round | Madison Brengle | Win | |
| Third Round | Camila Giorgi | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Shuai Zhang | Win | |
| Third Round | Jessica Pegula | Win | |
| Quarterfinals | Amanda Anisimova | Win | |
| Semifinals | Iga Swiatek | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Amanda Anisimova | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Bianca Andreescu | Win | |
| Quarterfinals | Anett Kontaveit | Win | |
| Semifinals | Paula Badosa | Win | |
| Final | Iga Swiatek | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 4 - Apr. 10 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Riske | Win | |
| Third Round | Amanda Anisimova | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Irina-Camelia Begu | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jasmine Paolini | Loss |
| Qatar TotalEnergies Open | ||
| Surface: Hard | Date: Feb. 20 - Feb. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alize Cornet | Win | |
| Third Round | Jil Teichmann | Win | |
| Quarterfinals | Iga Swiatek | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 14 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Marta Kostyuk | Win | |
| Second Round | Petra Kvitova | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Storm Sanders | Win | |
| Second Round | Xinyu Wang | Win | |
| Third Round | Marketa Vondrousova | Win | |
| Fourth Round | Kaia Kanepi | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 10 - Jan. 15 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Rebecca Peterson | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 3 - Jan. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kaja Juvan | Loss |
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