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| Eugene Korea Open Tennis Championships | ||
| Surface: Hard | Date: Sep. 26 - Oct. 2 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye |
| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Kyle Edmund | Win | 6-3, 7-5, 6-2 |
| Second Round | Tim Van Rijthoven | Win | 6-7 (4-7), 6-4, 6-4, 6-4 |
| Third Round | Tommy Paul | Win | 7-6 (7-3), 6-7 (5-7), 7-6 (7-2), 5-7, 6-0 |
| Fourth Round | Corentin Moutet | Win | 6-1, 6-2, 6-7 (4-7), 6-2 |
| Quarterfinals | Matteo Berrettini | Win | 6-1, 6-4, 7-6 (7-4) |
| Semifinals | Karen Khachanov | Win | 7-6 (7-5), 6-2, 5-7, 6-2 |
| Final | Carlos Alcaraz | Loss | 4-6, 6-2, 6-7 (1-7), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ben Shelton | Loss |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alex Molcan | Win | |
| Third Round | Roberto Bautista Agut | Win | |
| Quarterfinals | Felix Auger-Aliassime | Win | |
| Semifinals | Hubert Hurkacz | Loss |
| EFG Suisse Open Gstaad | ||
| Surface: Clay | Date: Jul. 18 - Jul. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Win | |
| Quarterfinals | Jaume Munar | Win | |
| Semifinals | Albert Ramos-Vinolas | Win | |
| Final | Matteo Berrettini | Win |
| Nordea Open | ||
| Surface: Clay | Date: Jul. 11 - Jul. 17 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Francisco Cerundolo | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Albert Ramos-Vinolas | Win | |
| Second Round | Ugo Humbert | Loss |
| cinch Championships | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Ryan Peniston | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Jo-Wilfried Tsonga | Win | |
| Second Round | Emil Ruusuvuori | Win | |
| Third Round | Lorenzo Sonego | Win | |
| Fourth Round | Hubert Hurkacz | Win | |
| Quarterfinals | Holger Rune | Win | |
| Semifinals | Marin Cilic | Win | |
| Final | Rafael Nadal | Loss |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 15 - May 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benoit Paire | Win | |
| Quarterfinals | Thanasi Kokkinakis | Win | |
| Semifinals | Reilly Opelka | Win | |
| Final | Joao Sousa | Win |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 8 - May 15 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Botic van de Zandschulp | Win | |
| Third Round | Jenson Brooksby | Win | |
| Quarterfinals | Denis Shapovalov | Win | |
| Semifinals | Novak Djokovic | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 28 - May 8 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dusan Lajovic | Loss |
| BMW Open by American Express | ||
| Surface: Red Clay | Date: Apr. 25 - May 1 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alex Molcan | Win | |
| Quarterfinals | Botic van de Zandschulp | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 18 - Apr. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Brandon Nakashima | Win | |
| Third Round | Emil Ruusuvuori | Win | |
| Quarterfinals | Pablo Carreno Busta | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Holger Rune | Win | |
| Third Round | Grigor Dimitrov | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Henri Laaksonen | Win | |
| Third Round | Alexander Bublik | Win | |
| Fourth Round | Cameron Norrie | Win | |
| Quarterfinals | Alexander Zverev | Win | |
| Semifinals | Francisco Cerundolo | Win | |
| Final | Carlos Alcaraz | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Christopher Eubanks | Win | |
| Third Round | Nick Kyrgios | Loss |
| Argentina Open | ||
| Surface: Clay | Date: Feb. 7 - Feb. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roberto Carballes Baena | Win | |
| Quarterfinals | Federico Coria | Win | |
| Semifinals | Federico Delbonis | Win | |
| Final | Diego Schwartzman | Win |
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