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| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 16 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Elise Mertens | Win | 4-6, 6-2, 6-3 |
| Second Round | Caroline Garcia | Win | 6-4, 6-4 |
| Third Round | Ashleigh Barty |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 29 - May 9 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Elena Vesnina | Win | 6-1, 6-4 |
| Second Round | Kiki Bertens | Win | 6-4, 6-3 |
| Third Round | Petra Kvitova | Loss | 3-6, 6-4, 4-6 |
| Tennis Championship Istanbul | ||
| Surface: Red Clay | Date: Apr. 19 - Apr. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Win | 6-4, 3-6, 7-6 (7-4) |
| Second Round | Kaia Kanepi | Win | 6-4, 6-3 |
| Quarterfinals | Ana Bogdan | Win | 2-6, 6-3, 6-3 |
| Semifinals | Elise Mertens | Loss | 1-6, 4-6 |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 5 - Apr. 11 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Desirae Krawczyk | Win | 6-1, 6-2 |
| Second Round | Emma Navarro | Win | 6-4, 6-4 |
| Third Round | Kurumi Nara | Win | 6-0, 6-3 |
| Quarterfinals | Sloane Stephens | Win | 6-3, 6-4 |
| Semifinals | Paula Badosa | Win | 6-3, 6-3 |
| Final | Danka Kovinic | Win | 6-4, 6-2 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 23 - Apr. 4 | Seed: 32 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Danielle Collins | Win | 6-3, 6-2 |
| Third Round | Aryna Sabalenka | Loss | 6-7 (4-7), 4-6 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Mar. 15 - Mar. 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kamilla Rakhimova | Win | 7-5, 3-6, 7-6 (7-5) |
| Quarterfinals | Daria Kasatkina | Loss | 6-1, 1-6, 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Mar. 7 - Mar. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Pavlyuchenkova | Win | 7-6 (7-3), 6-2 |
| Second Round | Belinda Bencic | Loss | 4-6, 7-5, 4-6 |
| Qatar Total Open 2021 | ||
| Surface: Hard | Date: Mar. 1 - Mar. 6 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Garbine Muguruza | Loss | 2-6, 6-7 (4-7) |
| Adelaide International | ||
| Surface: Hard | Date: Feb. 22 - Feb. 27 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Loss | 3-6, 6-7 (4-7) |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 32 |
| Round | Opponent | W / L | Result |
| First Round | Marta Kostyuk | Win | 6-2, 7-6 (7-5) |
| Second Round | Varvara Gracheva | Win | 5-7, 6-2, 6-2 |
| Third Round | Simona Halep | Loss | 1-6, 3-6 |
| Grampians Trophy | ||
| Surface: Hard | Date: Feb. 3 - Feb. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Heather Watson | Win | 6-2, 6-2 |
| Second Round | Ann Li | Loss | 5-7, 3-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anett Kontaveit | Win | 7-5, 6-1 |
| Second Round | Bianca Turati | Win | 6-2, 6-1 |
| Third Round | Paula Badosa | Win | 6-4, 4-6, 6-1 |
| Quarterfinals | Elina Svitolina | Win | 5-7, 6-3, 7-6 (7-3) |
| Semifinals | Marta Kostyuk | Win | 7-6 (10-8), 6-4 |
| Final | Aryna Sabalenka | Loss | 2-6, 2-6 |
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